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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 118
Article Submitted : 21508
Article Published : 8513
Total Authors : 22399
Total Reviewer : 805
Total Countries : 158
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| Paper Title: | Role of EGFR Inhibitor in Lung Cancer |
| Authors Name: | Mr. Yash M. Agrawal , Ms. Shubhangi Manikpuriya , Dr. Gajanan S. Sanap |
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IJRTI_185801
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| Published Paper Id: | IJRTI2304007 |
| Published In: | Volume 8 Issue 4, April-2023 |
| DOI: | |
| Abstract: | Lung cancer, also known as lung carcinoma (since about 98–99% of all lung cancers are carcinomas), is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lungLymphomas and melanomas (from lymphoid and melanocyte cell lineages) can also rarely result in lung cancer. In 2005, the total number of new lung cancer cases in china was over 500,000. According to GLOBOCAN 2012,lung cancer is the most common malignancy and cause of cancer mortality in China, representing 21% of all cancers and 27% of all cancer-related deaths Lung cancer incidence and mortality is higher in eastern China and in urban areas, which has been attributed to westernization of lifestyle. EGFR is a transmembrane tyrosine kinase receptor, which is one of the ErbB family of receptors. The ErbB family includes EGFR (ErbB1), ERBB2 (HER2/neu), ERBB3 (HER3), and ERBB4 (HER4). Also known EGFR tyrosine kinase inhibitor, epidermal growth factor receptor inhibitor. EGFR kinase domain mutations including exon 19 deletion, L858R and T790M increase kinase activity of EGFR, leading to the hyperactivation of downstream signaling pathways including MAPK, PI3K/Akt/mTOR, and IL-6/JAK/STAT3 which promote tumorigenesis of NSCLC cells. |
| Keywords: | Lung cancer, EGFR, EGFR inhibitor, EGFR – TKIs |
| Cite Article: | "Role of EGFR Inhibitor in Lung Cancer ", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 4, page no.32 - 42, April-2023, Available :http://www.ijrti.org/papers/IJRTI2304007.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2304007
Registration ID:185801
Published In: Volume 8 Issue 4, April-2023
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Page No: 32 - 42 Country: Aurangabad , Maharashtra , India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2304007 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2304007 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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