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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | DEVELOPMENT OF VALIDATED ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF ANTIANXIETY DRUGS BY LIQUID CHROMATOGRAPHY WITH QBD APPROACH |
| Authors Name: | Kanchan Dhanappa Nagrale , Rita D. Chakole , Manoj S. Charde |
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IJRTI_186276
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| Published Paper Id: | IJRTI2304234 |
| Published In: | Volume 8 Issue 4, April-2023 |
| DOI: | |
| Abstract: | The simple isocratic reverse-phase high-performance liquid chromatographic technique (RP-HPLC) used in this article was created for the simultaneous measurement of clonazepam (CZP) and escitalopram oxalate (EST) in pharmaceuticals and active pharmaceutical ingredients. As a stationary phase, a C18 column (id 4.6×150mm) was used to separate the two medicines. The mobile phase was a combination of 37:63 v/v isocratic methanol, , and Formic Acid buffer (pH 4.2 adjusted by formic acid). PDA detectors operating at 255 nm were used for detection. Escitalopram Oxalate and Clonazepam were separated by a single chromatographic run with (RT = 3.979 minutes and 6.085 minutes, respectively). Escitalopram Oxalate had a satisfactory linear relationship, as evidenced by the calibration plot's r2 = 0.998, r2 = 0.999 for Clonazepam in the concentration range of 5 g/ml to 25 g/ml, and for Escitalopram Oxalate in the concentration range of 50 g/ml to 250 g/ml. Escitalopram Oxalate and Clonazepam both had retrievals of 99.45% and 99.49%, respectively. As per ICH guidelines for linearity, precision, accuracy, specificity, limit of detection, limit of quantification, robustness, and stability, the developed analytical technique was validated and confirmed to be acceptable. Escitalopram Oxalate and Clonazepam were subjected to a variety of stress conditions, including acid, base, heat, photolytic, and oxidative degradation, and the peaks of the degraded product could be reliably distinguished from the peaks of the pure medication. This technique is simple, efficient, and suitable for standard quality control analysis. |
| Keywords: | Reverse Phase HPLC; Escitalopram Oxalate; Clonazepam; Validation; Degradation study |
| Cite Article: | "DEVELOPMENT OF VALIDATED ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF ANTIANXIETY DRUGS BY LIQUID CHROMATOGRAPHY WITH QBD APPROACH", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 4, page no.1423 - 1429, April-2023, Available :http://www.ijrti.org/papers/IJRTI2304234.pdf |
| Downloads: | 000205372 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2304234
Registration ID:186276
Published In: Volume 8 Issue 4, April-2023
DOI (Digital Object Identifier):
Page No: 1423 - 1429 Country: Solapur, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2304234 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2304234 |
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ISSN: 2456-3315
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