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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 117
Article Submitted : 21307
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Total Authors : 22301
Total Reviewer : 802
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| Paper Title: | FORMULATION AND DEVELOPMENT OF THERMOREVERSIBLE NASAL IN SITU GEL BY COMBINING ANTIDIABETIC DRUG AND CURCUMIN TO TREAT TYPE-3 DIABETES AND QUALITY TESTS EVALUATED |
| Authors Name: | Anuja Anku , K. Maryswarnalatha , T. Srilakshmi |
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IJRTI_186863
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| Published Paper Id: | IJRTI2305173 |
| Published In: | Volume 8 Issue 5, May-2023 |
| DOI: | |
| Abstract: | The present research was focused to develop the formulation containing combination of antidiabetic agent with natural antioxidant to manage diabetes-induced Alzheimer disease in elderly population with Type-2 diabetes. The thermoreversible in-situ gel formulations for nasal administration were developed to improve patient compliance, nasal bioavailability of drugs by increasing its nasal retention time and checked the effect of temperature on the preparation of formulation. The Metformin and Curcumin was used as model therapeutic agents. Combination of Curcumin with Metformin act synergistically on dyslipidaemia and oxidative stress, as well as increased PON 1 level which are major cause of AD. The in-situ gelation system was prepared by cold method with the use of Poloxamer P188, which has the property of thermo reversible gelation, Sodium alginate, Carbopol 940 and HPMC K100 were used as the mucoadhesive agents which will improve the absorption of drugs by increasing the contact time with nasal mucosa. Totally 12 formulations were prepared with Carbopol 940, Sodium alginate and HPMC K100 in varying concentrations. The prepared in-situ gel was evaluated for various quality control tests such as its gelation temperature, mucoadhesive potency, drug content, gelation time, viscosity and in vitro drug diffusion study. |
| Keywords: | Metformin, Curcumin, HPMC k100, Carbopol 940, Poloxamer P188, Diabetes-induced Alzheimer’s, in situ gel, Cold method. |
| Cite Article: | "FORMULATION AND DEVELOPMENT OF THERMOREVERSIBLE NASAL IN SITU GEL BY COMBINING ANTIDIABETIC DRUG AND CURCUMIN TO TREAT TYPE-3 DIABETES AND QUALITY TESTS EVALUATED", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 5, page no.1115 - 1160, May-2023, Available :http://www.ijrti.org/papers/IJRTI2305173.pdf |
| Downloads: | 000205299 |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2305173
Registration ID:186863
Published In: Volume 8 Issue 5, May-2023
DOI (Digital Object Identifier):
Page No: 1115 - 1160 Country: Hyderabad, Telangana, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2305173 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2305173 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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