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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 115
Article Submitted : 19455
Article Published : 8041
Total Authors : 21252
Total Reviewer : 769
Total Countries : 144
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| Paper Title: | Development of high concentrated IgE antibody for anti-asthmatic therapy |
| Authors Name: | Om Narayan , Kaushal Joshi , Sumit Shah, Sudharti Gupta , Kiran Avadhani, Bruce Weaver, Tarun Gupta , Shalini Sharma, Chandramauli Rawal, Divya Tailwani |
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IJRTI_187062
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| Published Paper Id: | IJRTI2306004 |
| Published In: | Volume 8 Issue 6, June-2023 |
| DOI: | |
| Abstract: | Asthma, allergic asthma and chronic idiopathic urticaria are almost invariably accompanied by elevated levels of IgE. Omalizumab is a recombinant DNA-derived humanized monoclonal antibody that selectively binds to human immunoglobulin (IgE). The antibody has a molecular weight of approximately 149 kDa. The liquid formulations of omalizumab are pharmacologically effective at high concentrated formulation, results in substantial increase in the protein-protein interaction and thereby increasing the viscosity of the formulation. The present study attempts to develop and optimize high concentration liquid formulation for omalizumab having high monomer, low aggregates, and desirable viscosity. The formulations were prepared by using different buffers, amino acids, and surfactants. All formulations were analysed for viscosity at fixed protein concentration. Based viscosity data, formulations were short listed and charged for stability at 37℃ up to one month. Stability samples at different time points were analysed for aggregation behaviour. Samples were also analysed for acidic and basic species. Based on data trend, the formulation was finalized and applied in the treatment of Asthma, allergic asthma and chronic idiopathic urticaria as subcutaneous administration. |
| Keywords: | Omalizumab, anti-IgE antibody, high concentration. |
| Cite Article: | "Development of high concentrated IgE antibody for anti-asthmatic therapy", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 6, page no.17 - 22, June-2023, Available :http://www.ijrti.org/papers/IJRTI2306004.pdf |
| Downloads: | 000205171 |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2306004
Registration ID:187062
Published In: Volume 8 Issue 6, June-2023
DOI (Digital Object Identifier):
Page No: 17 - 22 Country: Ahmedabad, , Gujarat, India Research Area: Other Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2306004 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2306004 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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