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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 115
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| Paper Title: | Spectrum of Hemoglobinopathies diagnosed by High Performance Liquid Chromatography: A cross sectional study |
| Authors Name: | Dr Sakina Naaz , Dr Md Iqbal Ali , Dr Rabia Naaz |
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IJRTI_188149
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| Published Paper Id: | IJRTI2310011 |
| Published In: | Volume 8 Issue 10, October-2023 |
| DOI: | |
| Abstract: | Background: Inherited abnormalities of hemoglobin synthesis include a varieties of disorders. Identification of these disorders is immensely important epidemiologically and aid in prevention of more serious hemoglobin disorders. Aims: High performance liquid chromatography (HPLC) forms an important tool for accurate diagnosis of various hemoglobin disorders. Early detection yields in better prognosis. About 150 cases have been studied for various hemoglobin disorders found in our region. Material and Methods: The study was conducted in a retrospective manner and various findings like hemoglobin's and patients symptoms were noted. HPLC helps in better diagnosis. Results and Conclusion: Abnormal hemoglobin fractions on HPLC were seen in 31 of the 150 cases studied. Of this, the beta thalassemia trait was the predominant abnormality with a total of 14 cases (9.33%). There were 1(0.66%) cases of beta thalassemia major. Sickle cell trait, sickle cell disease with one case of alpha chain variant were found. Detection of this abnormal hemoglobin, particularly keeping in mind a high prevalence of Hb A2, will help in prevention of more serious hemoglobinopathies including beta thalassemia major. Premarriage counselling and use of HPLC helps in early detection and management of various hemoglobin disorders. |
| Keywords: | HPLC, hemoglobinopathies, hemoglobin variants, thalassemia |
| Cite Article: | "Spectrum of Hemoglobinopathies diagnosed by High Performance Liquid Chromatography: A cross sectional study", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 10, page no.65 - 70, October-2023, Available :http://www.ijrti.org/papers/IJRTI2310011.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2310011
Registration ID:188149
Published In: Volume 8 Issue 10, October-2023
DOI (Digital Object Identifier):
Page No: 65 - 70 Country: Kolkata, West Bengal, India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2310011 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2310011 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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