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Impact Factor : 8.14

Issue per Year : 12

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Paper Title: Antiretroviral Related Adverse Effect - A Retrospective Observational Cohort Study
Authors Name: Julisa Suwal , Dr. Shibi Mary Thomas , Dr. Balakeshwa Ramaiah
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IJRTI_188724
Published Paper Id: IJRTI2312073
Published In: Volume 8 Issue 12, December-2023
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Abstract: Abstract Context: This study focuses on investigations of the antiretroviral therapy and other confounding factors in causing the adverse effects. Aims: People living with HIV (PLWH) are more likely to develop comorbidities related to ageing chronic HIV, and the toxicity of long-term antiretroviral therapy (ART). This study aims to investigate antiretroviral therapy and their major adverse effect after its prolonged use. Settings and designs: Tertiary care hospital and a retrospective observational cohort study. Methods and materials: A retrospective observational study was conducted in the inpatient and Outpatient departments of the Hospital. The patients who met the criteria were enrolled in the study. Baseline information such as demographic details was obtained. Drug-related data was collected and documented in a suitably designed data collection form. The follow ups and the adverse effect caused by the medicine that occurred in a patient was analyzed. Results: Out of 43 patients 24(%) were males. The average age of the study participants were 48 years. 18 patients were reported to have 23 (53.49%) cumulative adverse drug effects. A total of 26 patients were observed to be affected by an opportunistic infection. Out of all the infections, Oral candidiasis (29%) was frequently seen opportunistic infections. Dyslipidemia (26%) was the most observed ADR among all the patients. A total of 12 patients were found to have both an adverse effect along with an opportunistic infection. It was found that there was no any correlation between the CD4 count of the patient and the adverse drug reactions. In this study it was found that the longer duration of ART increases the chances of ADR occurrence. As per Naranjo scale when ADR events were evaluated for causality, it was observed that majority (66.67%) of the events were probable in nature with the score of 5-8. While the remaining (22.22%) were possible in nature having a score in between 1-4 and definite (11.11%) with a score of 9. Conclusions: ADR was found to be highly prevalent in those patients who were having ART for a prolong period of time. The ART regimen d4T+3TC+NVP regimen was found to cause more adverse effects, followed by AZT +3TC +NVP and TDF + 3TC + EFV. The majority of ADR satisfied ‘probable’ category and rest were ‘possible’ and ‘definite’ category.
Keywords: ART Therapy, ADR, HIV- AIDS, Toxicity
Cite Article: "Antiretroviral Related Adverse Effect - A Retrospective Observational Cohort Study", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 12, page no.512 - 521, December-2023, Available :http://www.ijrti.org/papers/IJRTI2312073.pdf
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ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2312073
Registration ID:188724
Published In: Volume 8 Issue 12, December-2023
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Page No: 512 - 521
Country: Bangalore, Karnataka, India
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2312073
Published Paper PDF: https://www.ijrti.org/papers/IJRTI2312073
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED, Journal Starting Year (ESTD) : 2016

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