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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Issue: March 2026
Volume 11 | Issue 3
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 118
Article Submitted : 22135
Article Published : 8686
Total Authors : 22851
Total Reviewer : 819
Total Countries : 160
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| Paper Title: | Formulation and Evaluation of Corticosteroid Lyophilized Injection for Arthritis Treatment |
| Authors Name: | D. Saranya , A. N. Rajalakshmi Duraivel , S. Padmapriya |
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IJRTI_189351
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| Published Paper Id: | IJRTI2403060 |
| Published In: | Volume 9 Issue 3, March-2024 |
| DOI: | |
| Abstract: | This research work focuses on the development of a formulation for a corticosteroid drug, achieved through systematic experimentation and analysis of prior data to understand the impact of process settings and material qualities on product quality. Physicochemical investigations were conducted following established protocols, referencing the United States Pharmacopoeia. The liquid dosage form of the drug was found to be unstable, necessitating its conversion to a solid dosage form via lyophilization due to its thermo-labile nature. Prior to formulation, the active pharmaceutical ingredient (API) underwent comprehensive assessment for various parameters, meeting acceptable standards. The API was processed using a magnetic stirrer to create a liquid injection, subsequently lyophilized to yield a stable lyophilized cake. Evaluation of the resulting lyophilized injection included API assay, reconstitution time, and pH analysis, passing visual inspection for the absence of foreign particles. High-performance liquid chromatography (HPLC) analysis was employed to detect related substances, ensuring compliance with regulatory specifications. This research underscores the importance of precise formulation techniques like lyophilization in pharmaceutical development to ensure product stability and efficacy. |
| Keywords: | Lyophilization, corticosteroids, preformulation study, formulation, evaluation, stability loading, results and conclusion. |
| Cite Article: | "Formulation and Evaluation of Corticosteroid Lyophilized Injection for Arthritis Treatment", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.9, Issue 3, page no.414 - 422, March-2024, Available :http://www.ijrti.org/papers/IJRTI2403060.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2403060
Registration ID:189351
Published In: Volume 9 Issue 3, March-2024
DOI (Digital Object Identifier):
Page No: 414 - 422 Country: puducherry, Puducherry, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2403060 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2403060 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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