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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Issue: March 2026
Volume 11 | Issue 3
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 118
Article Submitted : 22135
Article Published : 8686
Total Authors : 22851
Total Reviewer : 819
Total Countries : 160
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| Paper Title: | Formulation and Evaluation of Extended release Vaginal Tablets for the Treatment of Vulvo vaginal Atrophy using Top Spray Technology |
| Authors Name: | Nivetha V , A.N. Rajalakshmi , S. Padmapriya |
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IJRTI_189392
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| Published Paper Id: | IJRTI2403073 |
| Published In: | Volume 9 Issue 3, March-2024 |
| DOI: | |
| Abstract: | Vulvo Vaginal Atrophy (VVA), impacting approximately fifty percentage of postmenopausal females, arises from diminished estrogen concentrations, precipitating a multitude of undesirable and distressing symptoms. An ideal therapy should balance benefits, risks, patient adherence, and cost-effectiveness, influencing its adoption among symptomatic women. This research article emphasizes on formulation of an optimised product for the treatment of this prevalent disease. The suitable API falling in BCS class two which is a potent hormonal molecule was selected for the formulation. The API was investigated for its preformulation studies and suitable excipients were selected based on various literature studies so as to prolong the release of the dosage form in accordance to the patient compliance. Process optimisation was done beginning with direct compression followed by wet granulation, non aqueous granulation leading to the novel technique of top spray technology with drug suspension preparation in fluidized bed processor. Succeeding the process optimisation, formula optimisation was carried out and an optimized product with desirable evaluative results were obtained. Evaluation parameters such as pre compression and post compression parameters are discussed in this research article. |
| Keywords: | Vaginal tablets, Vulvo Vaginal Atrophy, preformulation study, formulation, evaluation, Top spray technique, extended release. |
| Cite Article: | "Formulation and Evaluation of Extended release Vaginal Tablets for the Treatment of Vulvo vaginal Atrophy using Top Spray Technology", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.9, Issue 3, page no.514 - 524, March-2024, Available :http://www.ijrti.org/papers/IJRTI2403073.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2403073
Registration ID:189392
Published In: Volume 9 Issue 3, March-2024
DOI (Digital Object Identifier):
Page No: 514 - 524 Country: Tiruppur, Tamilnadu, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2403073 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2403073 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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