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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | COMMON CLASSIFICATION OF AEDS DRUGS AND PATHOPHYSIOLOGY OF CLINICAL PRACTICE |
| Authors Name: | Elamurugan K , Madhu S , Reshma , Esther Rani , Selvakumar.S. |
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IJRTI_189581
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| Published Paper Id: | IJRTI2404047 |
| Published In: | Volume 9 Issue 4, April-2024 |
| DOI: | |
| Abstract: | This article describes clinical antiepileptic drugs (AEDs) that are available for the treatment of epilepsy. Epilepsy is characterized by repeated occurrences of seizures. Epileptic seizures are classified into focal onset (partial) and onset (generalized) types.Recent research that has expanded the knowledge of the cellular and molecular mechanisms that modulate neuronal excitability and network activity in the brain provides the development and discovery of antiepileptic drugs (AEDs). AED therapy starts with the selection of the most appropriate drug for individual patient according to a strategic decision based on the risk-benefit ratio. Beyond three generations of AEDs developed over the last 40 years, more effective, better tolerated, disease-modifying pharmacological therapies are still needed to improve seizure outcome and reduce the safety burden AEDs suppress seizures by blocking the voltage-gated Sodium channels (Phenytoin, Carbamazepine, Valproate, Lamotrigine, oxcarbazepine, topiramate), voltageactivated calcium channels (ethosuximide, gabapentin), Potentiation of GABA inhibition (barbiturates, Benzodiazepines, tiagabine), reduction of glutamate Excitation (felbamate, parampanel) and modification of the SV2 protein (levetiracetam, brivaracetam). Carbamazepine, phenytoin, and valproate are the firstline agents for partial onset seizures and generalized Onset seizures.Ethosuximide is the drug of choice for Absence seizures. AEDs are orally active and show unique PK features. Some AEDs cause enzyme induction and hence produce drug-drug interactions. Newer AEDs such as gabapentin, levetiracetam, tiagabine, and pregabalin do not cause enzyme induction. Despite many advances in AEDs, nearly 30% of people with epilepsy have drug-resistant or intractable seizures and presently, there is no cure for epilepsy. Thus, newer and more effective AEDs that can better prevent refractory seizures and modify the disease progression (epileptogenesis) are needed for curing epilepsy. |
| Keywords: | Epilepsy, classification of AED drugs, classified seizures, Pathophysiology, mechanism of action, Biomarker. |
| Cite Article: | "COMMON CLASSIFICATION OF AEDS DRUGS AND PATHOPHYSIOLOGY OF CLINICAL PRACTICE", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.9, Issue 4, page no.339 - 347, April-2024, Available :http://www.ijrti.org/papers/IJRTI2404047.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2404047
Registration ID:189581
Published In: Volume 9 Issue 4, April-2024
DOI (Digital Object Identifier):
Page No: 339 - 347 Country: Ariyalur , Tamilnadu , India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2404047 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2404047 |
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ISSN: 2456-3315
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