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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Exploring Adverse Drug Reactions of Combined Antihypertensive and Antidiabetic Therapies: A Hospital-based Pharmacovigilance Study |
| Authors Name: | Preet Zatale , Shubham Kamdi , Ishwar Kale , Anup Patekar , Prajwal Bhadke |
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IJRTI_189686
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| Published Paper Id: | IJRTI2404107 |
| Published In: | Volume 9 Issue 4, April-2024 |
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| Abstract: | Pharmacovigilance plays a critical role in detecting, assessing, understanding, and preventing adverse drug effects to optimize treatment outcomes and patient safety. Hypertension management increasingly relies on combination therapies, including angiotensin II receptor blockers (ARBs) and biguanide drugs like metformin, to achieve optimal control and reduce associated risks. Methods: A prospective observational study was conducted over six months to assess the real-world outcomes of ARB and biguanide combination therapy in hypertension and hyperglycemia management. Fifty patients with concurrent hypertension and diabetes were observed at a Super Specialty Hospital, capturing demographic data, medication use, and adverse events. Results: The study revealed various adverse drug reactions (ADRs) associated with combination therapy, including diarrhea (12%), dizziness (12%), rash/itching (12%), and polyuria (20%). Specific combinations, such as metformin + glimepiride + telmisartan, exhibited a 100% incidence of ADRs among prescribed patients. Conclusion: Comprehensive pharmacovigilance is crucial for optimizing treatment outcomes in patients with complex cardiovascular and metabolic conditions. This study provides valuable insights into the safety and efficacy of combined antihypertensive and antidiabetic therapies, emphasizing the need for vigilant monitoring and personalized treatment approaches to mitigate risks and enhance patient care. |
| Keywords: | Amlodipine, Metoprolol (Beta Blockers), Telmisartan-40 Mg, Angiotensin Receptor Blockers (ARBS), Antihypertensive Medications, Metformin, Glimepiride, Antidiabetic Medication, Ecospirin. |
| Cite Article: | "Exploring Adverse Drug Reactions of Combined Antihypertensive and Antidiabetic Therapies: A Hospital-based Pharmacovigilance Study", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.9, Issue 4, page no.773 - 780, April-2024, Available :http://www.ijrti.org/papers/IJRTI2404107.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2404107
Registration ID:189686
Published In: Volume 9 Issue 4, April-2024
DOI (Digital Object Identifier):
Page No: 773 - 780 Country: Nagpur, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2404107 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2404107 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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