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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 116
Article Submitted : 20481
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Total Authors : 21794
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| Paper Title: | SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-((1H-BENZOIMIDAZOL-2-YL)METHYL)-2-(PHENOXYMETHYL)-3H-BENZOIMIDAZOL-5-AMINE DERIVATIVES |
| Authors Name: | Pathare Balasaheb , Tanaji Bansode |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJRTI_200051
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| Published Paper Id: | IJRTI2412016 |
| Published In: | Volume 9 Issue 12, December-2024 |
| DOI: | http://doi.one/10.1729/Journal.42655 |
| Abstract: | In recent years, the rise of multidrug-resistant bacteria has spurred significant advancements in the development of new antimicrobial agents. Within the field of medicinal chemistry, benzimidazole has emerged as a crucial pharmacophore. This study focuses on the synthesis of a series of N-((1H-benzoimidazol-2-yl)methyl)-2-(phenoxymethyl)-3H-benzoimidazol-5-amine derivatives (6a-f), achieved through the reaction of substituted 2-(phenoxymethyl)-3H-benzoimidazol-5-amine derivatives with 2-chloromethyl benzimidazole. The structures of the synthesized compounds were confirmed using various spectroscopic techniques, including IR, 1H-NMR, 13C-NMR, and mass spectrometry. Furthermore, the antibacterial activity of compounds 6a-f was evaluated against Bacillus subtilis and Bacillus pumilus (gram-positive), as well as Escherichia coli and Pseudomonas aeruginosa (gram-negative) strains, utilizing the agar well diffusion method. Notably, compounds 6c and 6f exhibited significant antibacterial activity when compared to the standard drug Ciprofloxacin. |
| Keywords: | Benzimidazole derivatives, antibacterial activity, agar well diffusion method |
| Cite Article: | "SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-((1H-BENZOIMIDAZOL-2-YL)METHYL)-2-(PHENOXYMETHYL)-3H-BENZOIMIDAZOL-5-AMINE DERIVATIVES ", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.9, Issue 12, page no.a143-a150, December-2024, Available :http://www.ijrti.org/papers/IJRTI2412016.pdf |
| Downloads: | 000670 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID: IJRTI2412016
Registration ID:200051
Published In: Volume 9 Issue 12, December-2024
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.42655
Page No: a143-a150 Country: Thane, Maharashtra, India Research Area: Chemistry Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2412016 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2412016 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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