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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Exploring biomarkers for COVID-19: advances in biochemical and immunological diagnostics. |
| Authors Name: | Mr. Avinash V Chakinarpuwar |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJRTI_200294
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| Published Paper Id: | IJRTI2501034 |
| Published In: | Volume 10 Issue 1, January-2025 |
| DOI: | |
| Abstract: | The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has placed unprecedented demands on healthcare systems worldwide, underscoring the need for rapid and reliable diagnostic tools. Biomarkers, measurable indicators of biological processes, have become integral to the diagnosis, prognosis, and management of COVID-19. This review focuses on two major classes of biomarkers used in laboratory settings: biochemical and immunological markers. Biochemical biomarkers, such as inflammatory markers (C-reactive protein, ferritin, and procalcitonin), coagulation indicators (D-dimer and fibrinogen), and organ-specific markers (liver enzymes, renal function tests, and cardiac troponins), provide critical insights into the systemic effects of SARS-CoV-2. They are invaluable for assessing disease severity, identifying complications, and predicting outcomes. Immunological biomarkers, including molecular tests like reverse transcriptase polymerase chain reaction (RT-PCR) and serological assays for detecting antibodies (IgM, IgG, and neutralizing antibodies), are essential for confirming the presence of the virus and understanding the immune response. Cytokine profiling, particularly interleukin-6 (IL-6) levels, also plays a key role in identifying hyperinflammatory states such as cytokine storm syndrome. Despite their significant utility, challenges such as variability in biomarker expression, limited access to advanced diagnostic technologies, and potential cross-reactivity of immunological assays remain. This review highlights the current state of knowledge regarding these biomarkers, emphasizing their applications in clinical decision-making and patient monitoring. It also explores future directions, such as the development of multi-biomarker panels and point-of-care diagnostics, which promise to enhance the precision and accessibility of COVID-19 diagnostics. The integration of biochemical and immunological biomarkers has been instrumental in improving patient outcomes and public health strategies during the pandemic. As research continues to refine their use, these tools will remain critical in addressing not only COVID-19 but also other emerging infectious diseases. This review provides a comprehensive overview of their role, underscoring their importance in laboratory diagnostics and future pandemic preparedness |
| Keywords: | COVID-19, SARS-CoV-2, biomarkers, biochemical markers, immunological markers, diagnosis, prognosis, RT-PCR, serological assays, inflammatory markers, cytokine profiling, D-dimer, C-reactive protein (CRP), interleukin-6 (IL-6). |
| Cite Article: | "Exploring biomarkers for COVID-19: advances in biochemical and immunological diagnostics.", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 1, page no.a252-a262, January-2025, Available :http://www.ijrti.org/papers/IJRTI2501034.pdf |
| Downloads: | 000527 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2501034
Registration ID:200294
Published In: Volume 10 Issue 1, January-2025
DOI (Digital Object Identifier):
Page No: a252-a262 Country: Chandrapur, Maharashtra, India Research Area: Life Sciences Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2501034 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2501034 |
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ISSN: 2456-3315
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