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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
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Issue Published : 107
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| Paper Title: | DESIGN AND DEVELOPMENT OF MEDICATED CHOCOLATE CONTAINING ANTI-DEPRESSANT DRUG |
| Authors Name: | Zalak Sharma , Bhakti Shah |
| Download E-Certificate: | Download |
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IJRTI_200611
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| Published Paper Id: | IJRTI2502010 |
| Published In: | Volume 10 Issue 2, February-2025 |
| DOI: | |
| Abstract: | Objective: Design and development of medicated chocolate containing anti-depressant drug –Amitriptyline HCl. The formulation is optimized by Factorial design method. The main aim is To increase the patient compliance and reduce the rejection towards the other pharmaceutical products. Experimental Work: The medicated chocolate of Amitriptyline HCl is formulated using cocoa powder, cocoa butter, Mannitol and other suitable excipients. The bitter taste of the drug is masked by using beta cyclodextrin. Various trial batches are formulated to obtain the maximum drug release. 23 factorial design was employed for the optimization of the formulation. Pre formulation and post-formulation studies were done for the evaluation of the formulation. Result: The medicated chocolate containing Amitriptyline HCl (10mg) showed 97.2% drug release after 1 hour. The formulation has passed all the evaluation parameter. For stability improvement, Mannitol was added. The taste was also enhanced due to addition of mannitol. Conclusion: The studies indicates that the formulation is acceptable for the patients who are formed to get better taste, texture and also to decrease the level of rejection towards medications which has bitter taste. |
| Keywords: | Medicated chocolate, Amitriptyline HCl, Beta cyclodextrin, 23 full factorial design |
| Cite Article: | "DESIGN AND DEVELOPMENT OF MEDICATED CHOCOLATE CONTAINING ANTI-DEPRESSANT DRUG", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 2, page no.a78-a83, February-2025, Available :http://www.ijrti.org/papers/IJRTI2502010.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2502010
Registration ID:200611
Published In: Volume 10 Issue 2, February-2025
DOI (Digital Object Identifier):
Page No: a78-a83 Country: Ahmedabad, Gujarat, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2502010 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2502010 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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