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Recent advances in metagenomic sequencing and metabolomics have revealed a strong connection between gut microbiota and cardiovascular diseases (CVDs) such as coronary atherosclerosis, hypertension, and heart failure. Metabolites like trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), and bile acids (BAs) play key roles in the development, prevention, and treatment of CVDs. This review summarizes the latest findings on how these microbiota-related metabolites impact CVD progression. Similarly, next generation sequencing has improved our understanding of the microbiota's role in cancer development and treatment. Evidence suggests that modifying gut microbiota can enhance the effectiveness of therapies like immunotherapy, chemotherapy, and radiation. This review also examines emerging microbial interventions for cancer therapy and their potential to improve treatment outcomes.
Keywords:
Gut microbiota, cardiovascular diseases (CVDs), Cancer Immunotherapy, Chemotherapy, Fecal Microbiota Transplantation (FMT), Microbial Dysbiosis, Microbial Metabolites, Bacterial Consortia, Probiotics in Cancer, Gut–Tumour Interaction, Tumour Microenvironment (TME), Microbial Therapy, Immune System Modulation, Microbiome based Treatment, Biomarkers in Cancer Treatment.
Cite Article:
" GUT MICROBES ACTION ON CDV’S AND CANCERTHEARPY ", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 2, page no.b16-b39, February-2025, Available :http://www.ijrti.org/papers/IJRTI2502105.pdf
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ISSN:
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator