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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 118
Article Submitted : 21686
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| Paper Title: | "Small Worm, Big Impact: Exploring Neurotoxicant-Induced Parkinsonism in C. elegans": A Comprehensive Review |
| Authors Name: | SNEHA VERMA , RAMAKANT |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJRTI_203465
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| Published Paper Id: | IJRTI2505053 |
| Published In: | Volume 10 Issue 5, May-2025 |
| DOI: | |
| Abstract: | Caenorhabditis elegans has emerged as a robust in vivo platform for modeling Parkinson’s disease (PD)-like neurodegeneration triggered by environmental toxicants. Compounds such as rotenone, MPTP (via its active metabolite MPP⁺), and 6-hydroxydopamine (6-OHDA) reproduce central pathological features of PD, including dopaminergic (DAergic) neuron loss, mitochondrial impairment, oxidative stress, and behavioral anomalies. This review compiles findings from over 15 key studies, examining the cellular mechanisms of neurotoxicity, genetic influences on vulnerability, and the advantages of C. elegans for rapid drug discovery. |
| Keywords: | Caenorhabditis elegans, Parkinson’s disease, MPTP, Rotenone, dopaminergic neuron. |
| Cite Article: | ""Small Worm, Big Impact: Exploring Neurotoxicant-Induced Parkinsonism in C. elegans": A Comprehensive Review", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 5, page no.a505-a525, May-2025, Available :http://www.ijrti.org/papers/IJRTI2505053.pdf |
| Downloads: | 000420 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2505053
Registration ID:203465
Published In: Volume 10 Issue 5, May-2025
DOI (Digital Object Identifier):
Page No: a505-a525 Country: lucknow, UTTAR PRADESH, India Research Area: Life Sciences Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2505053 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2505053 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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