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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 116
Article Submitted : 20123
Article Published : 8195
Total Authors : 21632
Total Reviewer : 776
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| Paper Title: | Enhancement of solubility of poorly water soluble drugs by using Complexol: A cyclodextrin based Approach |
| Authors Name: | Ms.Ankita G. Jaunjal , Dr. Suparna S.Bakhale , Dr. Sachin W.Lohe , Dr. Sanjay P. Wate |
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IJRTI_204596
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| Published Paper Id: | IJRTI2506087 |
| Published In: | Volume 10 Issue 6, June-2025 |
| DOI: | |
| Abstract: | Poor water solubility limits the oral bioavailability of many BCS Class II drugs like Telmisartan. This study aims to enhance the solubility and dissolution rate of Telmisartan using inclusion complexes with Complexol-B (β-cyclodextrin) and Complexol-HP (hydroxypropyl-β-cyclodextrin). Complexes were prepared by kneading and co-evaporation methods in various drug-to-polymer ratios. Characterization was done using FTIR, DSC, PXRD, SEM, and UV-spectroscopy. Phase solubility studies confirmed increased solubility, particularly with Complexol-HP. The optimized complexes showed significantly improved dissolution compared to the pure drug and marketed formulations. Thus, cyclodextrin complexation is a promising strategy to improve solubility of poorly water-soluble drugs. |
| Keywords: | Cyclodextrin, inclusion complexes, poorly water soluble drugs. |
| Cite Article: | "Enhancement of solubility of poorly water soluble drugs by using Complexol: A cyclodextrin based Approach", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 6, page no.a735-a741, June-2025, Available :http://www.ijrti.org/papers/IJRTI2506087.pdf |
| Downloads: | 000396 |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2506087
Registration ID:204596
Published In: Volume 10 Issue 6, June-2025
DOI (Digital Object Identifier):
Page No: a735-a741 Country: Bhandara, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2506087 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2506087 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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