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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Formulation and Evaluation of Topical Niosomal Gel |
| Authors Name: | Vikram V. Bhoyar , Dr. Vikrant P. Wankhade , Tanvi S. Kokate , Neha S. Ghogare |
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IJRTI_204700
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| Published Paper Id: | IJRTI2506094 |
| Published In: | Volume 10 Issue 6, June-2025 |
| DOI: | |
| Abstract: | The present study focuses on the formulation and evaluation of a topical niosomal gel containing Naproxen, a non-steroidal anti-inflammatory drug (NSAID), to enhance its therapeutic efficacy and provide sustained drug release. Niosomes, which are non-ionic surfactant-based vesicles, were prepared using the ether injection method with Tween 80 and cholesterol in varying concentrations. Nine formulations were developed using a 3² factorial design and evaluated for particle size, zeta potential, entrapment efficiency, and in vitro drug diffusion. Among them, batch F9 exhibited optimal characteristics, including a particle size of 242.7 nm, zeta potential of -21.7 mV, entrapment efficiency of 95%, and drug content of 88.83%. The optimized niosomal suspension was incorporated into a Carbopol 940 gel to prepare the final niosomal gel formulation. The gel was further characterized for pH (6.2), spreadability, drug content (73.23%), viscosity, and in vitro drug release. Diffusion studies confirmed a sustained release of 55.81% over 6 hours, with drug release best fitting the Kosmeyer-Peppas model (R² = 0.9655), indicating controlled diffusion. The study concludes that niosomal gel offers a promising strategy for effective topical delivery of Naproxen with prolonged action and improved patient compliance. |
| Keywords: | Niosomal gel, Topical drug delivery, Formulation, Skin permeation, Surfactant, Topical drug delivery, Sustained release, Carbopol 940, Ether injection method, NSAIDs, Nanovesicular systems |
| Cite Article: | "Formulation and Evaluation of Topical Niosomal Gel", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 6, page no.a784-a795, June-2025, Available :http://www.ijrti.org/papers/IJRTI2506094.pdf |
| Downloads: | 000428 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2506094
Registration ID:204700
Published In: Volume 10 Issue 6, June-2025
DOI (Digital Object Identifier):
Page No: a784-a795 Country: Amravati, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2506094 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2506094 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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