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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 118
Article Submitted : 21653
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Total Authors : 22459
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| Paper Title: | Formulation and Evaluation of In-Situ gel for Antifungal Activity |
| Authors Name: | Sawant Viraj Sopan , Miss. Mane Kirti Chandrashekhar , Dr. Gurav Yogesh Anant |
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IJRTI_205180
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| Published Paper Id: | IJRTI2507038 |
| Published In: | Volume 10 Issue 7, July-2025 |
| DOI: | |
| Abstract: | The present study focuses on the formulation and evaluation of a Luliconazole-loaded in-situ gel intended for topical antifungal therapy. In-situ gel systems offer a novel approach to drug delivery by undergoing a sol-to-gel transformation in response to physiological stimuli such as temperature, pH, or ionic interactions. This mechanism facilitates localized, sustained release and enhances drug retention at the application site, thereby improving therapeutic efficacy and patient compliance. Luliconazole, a potent imidazole antifungal agent, was incorporated into a thermosensitive gel matrix using polymers like Poloxamer 407, HPMC, CMC, methyl cellulose, and sodium alginate. The formulations were characterized for pH, viscosity, gelation temperature and time, clarity, drug content, and in vitro antifungal activity against Candida albicans. The optimized formulation (F2) exhibited superior gel strength, desirable viscosity, controlled drug release, and a larger zone of inhibition compared to marketed preparations. These findings suggest that in-situ gel systems are promising platforms for effective and patient-friendly topical antifungal therapy. |
| Keywords: | Luliconazole, in-situ gel, antifungal activity, thermosensitive gel, sustained release, topical delivery, Poloxamer 407, Candida albicans. |
| Cite Article: | "Formulation and Evaluation of In-Situ gel for Antifungal Activity", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 7, page no.a317-a331, July-2025, Available :http://www.ijrti.org/papers/IJRTI2507038.pdf |
| Downloads: | 000388 |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2507038
Registration ID:205180
Published In: Volume 10 Issue 7, July-2025
DOI (Digital Object Identifier):
Page No: a317-a331 Country: Solapur, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2507038 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2507038 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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