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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Development and Validation of RP-HPLC Method for Simultaneous Determination of Metoprolol Succinate, Telmisartan, and Amlodipine Besylate in Synthetic Mixture |
| Authors Name: | Riya Patel , Riddhi Prajapati , Bhumika Patel , Nehal Nayak , Dr. Ravi R Patel |
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IJRTI_205774
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| Published Paper Id: | IJRTI2509001 |
| Published In: | Volume 10 Issue 9, September-2025 |
| DOI: | |
| Abstract: | A novel, simple, rapid, precise and highly efficient, isocratic liquid chromatography (RP-HPLC) method has been developed and validated for simultaneous estimation of amlodipine, metoprolol and telmisartan. Separation of all three compounds was achieved using Cosmosil C18 (250x4.6), 5µ column set at 25 °C temperature. Mobile phase consisted of a mixture of 20mMol KH2PO4: Acetonitrile:Methanol (30:30:40) %v/v flowing at a flow rate of 1.5 mL/min. Detection was carried out by UV detector set at 234 nm. Injection volume was kept at 5 µL. The retention times were found to be 3.913 min, 2.107, 8.859 minutes for amlodipine, metoprolol and telmisartan respectively. The calibration curve demonstrated linearity over the range of 25-75 µg/mL, 250-750 µg/mL, 200-600 µg/mL for amlodipine, metoprolol and telmisartan respectively with correlation coefficients of 0.999 for all three drugs. The recoveries were found to be in the ranges of 100.1-100.4%, 100.1-100.8%, 99.2-100.0% for amlodipine, metoprolol and telmisartan respectively. The method was found to be precise and robust with very less %RSD values. The method can be employed for routine quality control analysis. |
| Keywords: | Amlodipine, Metoprolol, telmisartan, RP-HPLC, validation, ICH |
| Cite Article: | "Development and Validation of RP-HPLC Method for Simultaneous Determination of Metoprolol Succinate, Telmisartan, and Amlodipine Besylate in Synthetic Mixture", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 9, page no.a1-a23, September-2025, Available :http://www.ijrti.org/papers/IJRTI2509001.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2509001
Registration ID:205774
Published In: Volume 10 Issue 9, September-2025
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Page No: a1-a23 Country: Gandhinagar , Gujarat, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2509001 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2509001 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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