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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Issue: March 2026
Volume 11 | Issue 3
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Impact Factor : 8.14
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| Paper Title: | Phytoconstituents with Anti-Biofilm and Anti-Inflammatory Activities in the Management of Urinary Tract Infections |
| Authors Name: | Ayesha Mohamed Shareef Shaikh |
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| Author Reg. ID: |
IJRTI_207216
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| Published Paper Id: | IJRTI2511032 |
| Published In: | Volume 10 Issue 11, November-2025 |
| DOI: | |
| Abstract: | Urinary tract infections (UTIs) continue to present significant health and economic concerns, particularly in cases involving recurrent or chronic infections. Conventional antibiotic therapy is often compromised by increasing antimicrobial resistance and the capacity of uropathogens to form biofilms on uroepithelial surfaces and indwelling medical devices. Phytoconstituents derived from medicinal plants are being explored as potential agents with anti-biofilm and anti-inflammatory properties that may influence the management of UTIs through multiple biological mechanisms. Compounds such as flavonoids, terpenoids, phenolic acids, alkaloids, and tannins have been examined for their ability to interfere with quorum sensing, reduce bacterial adhesion, and modulate host inflammatory responses. These activities could potentially alter the course of infection or complement existing therapeutic strategies. Experimental investigations have suggested that despite their therapeutic potential, many phytochemicals face limitations related to solubility, stability, and bioavailability. Nanotechnology-based delivery platforms are being considered to address these limitations. Nanoemulsions, liposomes, polymeric nanoparticles, and solid lipid nanoparticles are among the formulations being studied for targeted delivery, sustained release, and improved mucosal penetration. Such systems may also provide opportunities for co-delivery of multiple bioactive agents or combinations with conventional drugs. Recent research trends indicate an interest in integrating phytoconstituents with nanoformulation strategies to examine their impact on biofilm disruption, inflammatory modulation, and pathogen viability in the context of UTIs. Hypothetical models propose that optimized nanocarrier systems could influence pharmacokinetics and biodistribution, potentially affecting treatment outcomes in both in vitro and in vivo settings. Further exploration may focus on pathogen-specific interactions, host immune responses, dosing parameters, and safety profiles in preclinical and clinical trial designs. |
| Keywords: | Phytoconstituents, Urinary tract infections, Anti-biofilm potential, Anti-inflammatory activity, Nanoformulation strategies, Plant-derived compounds, Bioavailability, Antimicrobial resistance, Drug delivery systems, Experimental therapeutics |
| Cite Article: | "Phytoconstituents with Anti-Biofilm and Anti-Inflammatory Activities in the Management of Urinary Tract Infections", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 11, page no.a236-a245, November-2025, Available :http://www.ijrti.org/papers/IJRTI2511032.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2511032
Registration ID:207216
Published In: Volume 10 Issue 11, November-2025
DOI (Digital Object Identifier):
Page No: a236-a245 Country: mumbai, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2511032 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2511032 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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