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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 117
Article Submitted : 21318
Article Published : 8476
Total Authors : 22301
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| Paper Title: | "Stimuli-Responsive Pharmaceuticals: The Next Dimension with 4D Printing" |
| Authors Name: | Ms. Kuchekar S.D , Ms. Bhaldar F.M , Ms. Jagtap S.S , Ms. Mohire V.D , Ms. Barsing A.S |
| Download E-Certificate: | Download |
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IJRTI_206560
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| Published Paper Id: | IJRTI2512082 |
| Published In: | Volume 10 Issue 12, December-2025 |
| DOI: | |
| Abstract: | 4D printing (4DP) is an innovative advancement of 3D printing that adds a time-dependent functionality to printed objects. Introduced in 2013, 4DP enables the creation of structures that can transform their shape or behavior when exposed to external stimuli such as heat, light, pH, moisture, or magnetic fields. This is achieved by incorporating smart materials like Shape Memory Polymers (SMPs) and hydrogels into the printing process. SMPs allow objects to return to a pre-defined shape in response to environmental changes, while hydrogels—responsive to temperature, water, or light—are especially useful in biomedical applications like controlled drug delivery.The roots of additive manufacturing trace back to Chuck Hull’s invention of stereolithography (SLA) in 1986. Since then, the field has evolved significantly, and 4DP marks a transformative leap. It has found applications in diverse sectors such as aerospace (deployable satellites, morphing wings), biomedicine (self-expanding stents, personalized implants), pharmaceuticals (targeted drug release), soft robotics, and tissue engineering. In tissue engineering, for instance, 4DP is used to develop scaffolds that adapt to the body's conditions, aiding in regeneration. Technologies like machine learning (ML), finite element analysis (FEA), and computer-aided drug design (CADD) are enhancing 4DP through smarter modeling and predictive design. 4D bioprinting, an extension of this concept, introduces responsiveness into biological structures, improving therapeutic precision and customization. Despite its vast potential, 4DP still faces challenges including limited material availability, slow response times, and the complexity of integrating multiple materials. Specialized software and hardware are also required. However, with ongoing research and innovation, the technology holds promising future applications in space manufacturing, wound care, and even 5D/6D printing. With the global market expected to grow from USD 207.4 million in 2024 to over USD 4.44 billion by 2034, 4DP is poised to revolutionize adaptive and intelligent manufacturing. |
| Keywords: | 4D printing, smart materials, shape memory polymers, hydrogels, drug delivery, bioprinting, adaptive structures, tissue engineering, self-assembly. |
| Cite Article: | ""Stimuli-Responsive Pharmaceuticals: The Next Dimension with 4D Printing"", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 12, page no.a649-a660, December-2025, Available :http://www.ijrti.org/papers/IJRTI2512082.pdf |
| Downloads: | 000136 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2512082
Registration ID:206560
Published In: Volume 10 Issue 12, December-2025
DOI (Digital Object Identifier):
Page No: a649-a660 Country: -, -, India Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2512082 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2512082 |
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ISSN: 2456-3315
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