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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 117
Article Submitted : 21318
Article Published : 8476
Total Authors : 22301
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| Paper Title: | A Cross-Sectional Study on a Structured Histopathological Scoring System for Placental Changes in Normal and Hypertensive Disorders of Pregnancy |
| Authors Name: | Dr. Nafisa Parveen , Dr. B. S. Nithyananda , Dr. Naval Kishore Bajaj , Dr.Swetha Annaram |
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IJRTI_208936
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| Published Paper Id: | IJRTI2512168 |
| Published In: | Volume 10 Issue 12, December-2025 |
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| Abstract: | Background: Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and perinatal morbidity and mortality. Placental histopathology reflects the severity of uteroplacental insufficiency; however, lack of standardized reporting limits its clinical utility. Aim To evaluate placental histopathological changes in hypertensive disorders of pregnancy using a structured scoring system and correlate these findings with fetal outcomes. Materials and Methods This cross-sectional observational study included 214 placentae, comprising 107 normotensive and 107 hypertensive pregnancies, collected over two years at a tertiary care centre in Hyderabad. Placentae were examined grossly and microscopically using hematoxylin and eosin staining. A semi-quantitative scoring system assessed fibrin deposition, maternal floor infarction, syncytial knots, calcification, and villous basement membrane thickening. Statistical analysis was performed using SPSS v27. Results Placentae from hypertensive pregnancies showed significantly higher histopathological scores compared to normotensive controls (p < 0.05). Increased syncytial knots and fibrin deposition were the most frequent lesions. Higher lesion scores correlated significantly with prematurity, low birth weight, increased NICU admissions, and stillbirths, particularly in severe pre-eclampsia and eclampsia. Conclusion A structured histopathological scoring system provides an objective and reproducible method for placental reporting in hypertensive disorders of pregnancy and demonstrates strong correlation with adverse fetal outcomes. |
| Keywords: | Placenta, Hypertensive disorders of pregnancy, Histopathology, Scoring system, Fetal outcome |
| Cite Article: | "A Cross-Sectional Study on a Structured Histopathological Scoring System for Placental Changes in Normal and Hypertensive Disorders of Pregnancy", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 12, page no.b593-b603, December-2025, Available :http://www.ijrti.org/papers/IJRTI2512168.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2512168
Registration ID:208936
Published In: Volume 10 Issue 12, December-2025
DOI (Digital Object Identifier):
Page No: b593-b603 Country: HYDERABAD, TELANGANA, India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2512168 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2512168 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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