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Paper Title:
Efficacy of Neem (Azadirachta indica), Zardchob (Curcuma longa) and Filfil Seyah (Piper nigrum) in Elevated Ovarian Cancer Marker CA 125: A Single Case Study
Abstract
Background: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder frequently associated with menstrual irregularities, dysmenorrhea, acne and hyperandrogenism. Serum cancer antigen 125 (CA 125), although mainly used as a tumor marker for ovarian carcinoma, may also rise in benign gynecological conditions including PCOS. Traditional Unani medicine approaches reproductive disorders through correction of humoral imbalance and restoration of normal temperament (Mizaj) of reproductive organs. To evaluate the efficacy of Neem (Azadirachta indica), Zardchob (Curcuma longa) and Filfil Seyah (Piper nigrum) in reducing elevated CA 125 levels and improving symptoms associated with polycystic ovarian disease. A 24 year old unmarried female presented with severe dysmenorrhea, irregular menses, acne, hirsutism and mood swings. Ultrasonography revealed bilateral polycystic ovaries and CA 125 was elevated to 138.4 IU/mL. Neem capsule 250 mg twice daily and Zardchob + Filfil Seyah capsule (250 mg, ratio 100:5) twice daily for 10 months along with carbohydrate restricted, dairy free diet and light exercise. After treatment, CA 125 reduced to 13 IU/mL and ultrasonography showed normal ovarian morphology. Symptoms resolved completely with no adverse effects.
The herbal combination demonstrated potential benefit in improving PCOS associated symptoms and reducing CA 125 levels.
Keywords:
PCOS inflamation CA 125 Neem, Zardchob & Fil Fil Seyah
Cite Article:
"Efficacy of Neem (Azadirachta indica), Zardchob (Curcuma longa) and Filfil Seyah (Piper nigrum) in Elevated Ovarian Cancer Marker CA 125: A Single Case Study", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.11, Issue 3, page no.a125-a127, March-2026, Available :http://www.ijrti.org/papers/IJRTI2603020.pdf
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator