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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Issue: July 2026
Volume 11 | Issue 7
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Impact Factor : 8.14
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| Paper Title: | Formulation and Evaluation of a Gastroretentive Floating In Situ Gel of Vonoprazan Fumarate |
| Authors Name: | Mrs. Poonam Purkar , Miss. Sandhya Desai , Miss. Shubhangi Kandalakar , Miss. Shruti Jorwar , Dr. Promod Ingale |
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IJRTI_213647
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| Published Paper Id: | IJRTI2607010 |
| Published In: | Volume 11 Issue 7, July-2026 |
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| Abstract: | The present study aimed to formulate and evaluate a gastroretentive floating in situ gel system of Vonoprazan fumarate for prolonged gastric retention and sustained drug release. Vonoprazan fumarate, a new potassium-competitive acid blocker, exhibits powerful acid inhibition but may have a short gastric residence time in conventional dosage forms. To address this limitation, ion sensitive floating in situ gel was developed using sodium alginate as the main gelling polymer, guar gum and HPMC as release retarding agents, calcium carbonate as gas generating and cross linking agent and sodium citrate as calcium ion complexing agent. Nine formulations (F1-F9) were prepared and evaluated for physicochemical characteristics like pH, density, drug content, floating lag time and in vitro drug release. The pH of the formulations ranged from 7.53 to 8.50, which is suitable for oral administration. Density values were in the range 0.81–0.97 g/cm³ confirming good floating characteristics. The content of drug was found to be varying from 88.74% to 95.30% indicating uniform distribution of drug. Floating lag time was between 20 and 95 sec showing rapid buoyancy. Results: Formulation F5 showed optimum performance in vitro drug release studies showed sustained drug release over a long period. The drug release kinetics studies revealed the release pattern to follow Korsmeyer-Peppas and zero-order models. Stability studies confirmed the stability of the formulation during storage. The prepared gastroretentive floating in situ gel of Vonoprazan fumarate was achieved to improve gastric retention and sustained drug release and can be regarded as an effective delivery system for the management of acid related gastrointestinal disorders. |
| Keywords: | Vonoprazan fumarate, Gastroretentive drug delivery system, Floating in situ gel, Sodium alginate, Sustained release, Gastric retention |
| Cite Article: | "Formulation and Evaluation of a Gastroretentive Floating In Situ Gel of Vonoprazan Fumarate", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.11, Issue 7, page no.a83-a97, July-2026, Available :http://www.ijrti.org/papers/IJRTI2607010.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2607010
Registration ID:213647
Published In: Volume 11 Issue 7, July-2026
DOI (Digital Object Identifier):
Page No: a83-a97 Country: Pune, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2607010 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2607010 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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