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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 112
Article Submitted : 17566
Article Published : 7616
Total Authors : 20196
Total Reviewer : 740
Total Countries : 135
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| Paper Title: | Formulation and evaluation of fluconazole ointment |
| Authors Name: | Haleema.S.Siddiqui , Balaji Reddy , Nausheen Fatima , Mahboob Shareef , Mohammed Mustafa |
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| Author Reg. ID: |
IJRTI_182043
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| Published Paper Id: | IJRTI2205103 |
| Published In: | Volume 7 Issue 5, June-2022 |
| DOI: | |
| Abstract: | The key focus of this research study was to develop a fluconazole ointment using polyethylene glycol (water soluble) ointment base. Five formulations where each contains 0.5%w/w of fluconazole and 25%w/w of PEG 4000 with varying concentration of PEG 400 were formulated by the method of fusion. The prepared fluconazole ointments were examined visually, pH, Viscidness, Drug content, In-vitro drug release and Antifungal potency where dermatophyte fungi strain was used. Upon evaluation the formulation F5 showed highest % of drug content and antifungal activity and satisfactory results in all assessment parameters and best expressed by Higuchi model indicating that optimum concentration of PEG 4000 and PEG 400 form a potent ointment base for azole antifungals. Through this research study we intend to show PEG ointment base as a safe, efficacious ointment base for Fluconazole and similar azole antifungals that can prove to be effective against fungal dermatological infections. |
| Keywords: | Fluconazole, Polyethylene glycol, Dermatophyte fungi, Antifungal activity |
| Cite Article: | "Formulation and evaluation of fluconazole ointment", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 5, page no.609 - 612, June-2022, Available :http://www.ijrti.org/papers/IJRTI2205103.pdf |
| Downloads: | 000205118 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2205103
Registration ID:182043
Published In: Volume 7 Issue 5, June-2022
DOI (Digital Object Identifier):
Page No: 609 - 612 Country: Hyderabad/, Telangana, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2205103 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2205103 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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