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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
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Published Paper Details
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| Paper Title: | Epithelial Mesenchymal Transition In Oral Squamous Cell Carcinoma |
| Authors Name: | Dr. Puja Bansal , Farheen Afsar Khan , Sonali Bimi , Vipin Pratap Singh |
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IJRTI_182102
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| Published Paper Id: | IJRTI2205140 |
| Published In: | Volume 7 Issue 5, May-2022 |
| DOI: | |
| Abstract: | During embryonic development, Epithelial mesenchymal transition, EMT is an important process which enables the epithelial cells to acquire mesenchymal, fibroblast-like properties and show reduced intercellular adhesion and increased motility. During cancer progression, the activation of EMT permits cancer cells to acquire migratory, invasive, and stem like properties. Various Neoplasias and Chronic inflammation of tissues appropriate and subvert similar processes as Epithelial Mesenchymal Transition associated with embryo implantation, embryogenesis, and organ development. Recent advances have shown an enormous amount of evidence pointing towards a critical role of EMT like events during tumor progression and malignant transformation, providing the nascent cancer cells with invasive and metastatic properties. Activation of the phosphatidylinositol kinase PI3K AKT axis has recently been emerging as a central feature of EMT, and their role in EMT during development of cancer will be discussed in the article, with a focus on E cadherin regulation along with several other oncogenic pathways like peptide growth factors, Src, Ras, Ets, integrin, Wnt b catenin and Notch which induce EMT and downregulates the cell adhesion molecule E Cadherin. The article also aims to discuss the Biomarkers for EMT, such as Epithelial Plasticity which can help identify at least three types of EMT, Cell surface markers, Cytoskeletal Markers, etc. and how they can be used as a screening tool for early diagnosis and better prognosis of Oral Squamous Cell Carcinoma. |
| Keywords: | Epithelial-mesenchymal-transition, E-cadherin, oral carcinoma, metastasis, biomarkers. |
| Cite Article: | "Epithelial Mesenchymal Transition In Oral Squamous Cell Carcinoma ", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 5, page no.852 - 855, May-2022, Available :http://www.ijrti.org/papers/IJRTI2205140.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2205140
Registration ID:182102
Published In: Volume 7 Issue 5, May-2022
DOI (Digital Object Identifier):
Page No: 852 - 855 Country: Gautam Budhdha Nagar, Uttar Pradesh, India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2205140 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2205140 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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