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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | In-silico screening of potential immune-boosting phytocompounds from several medicinal plants against SARS-CoV-2 |
| Authors Name: | Rahul koli , V. S. Mannur , Shankar Gharge , Ravichandra Nadagouda |
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IJRTI_182394
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| Published Paper Id: | IJRTI2206070 |
| Published In: | Volume 7 Issue 6, June-2022 |
| DOI: | |
| Abstract: | Ayurvedic medicines are the traditional medicinal system of India and they are usually composed of mixture of herbal drugs or the extracts of the active principles of various plants having therapeutic activities. Based on the available literature the following plants Tinospora cardifolia (Guduchi), Piper longum (Pippali), Glycyrrhiza glabra (Licorice) and Withania somnifera (Ashwagandha) are used as a preventive measure against various diseases, which acts by boosting the immunity against the severity of infection caused by novel coronavirus (COVID-19). In the present study the selected active constituents from above mentioned plants were used to carry out in-silico studies against covid19. MolSoft and Admet SAR2.0 were used to predict the drug likeness score and pharmacokinetic profile of phytoconstituents and protein-ligand interaction of selected phytocompounds were predicted from AutoDock Vina by PyRx 0.8 and visualization is done by BIOVIA Discovery Studio 2021. Present study concluded that, amongst all the selected phytocompounds, Withanolide D has shown good binding affinity of -8.9kcal/mol with COVID-19 main protease 3CLpro and also Withanolide D has shown good binding affinity of -9.1kcal/mol with SARS-CoV main peptidase 2GTB. The study provides the scientific evidence of this Ayurvedic formulation to combat COVID-19. |
| Keywords: | Molecular docking, Herbal, Withanolide D, COVID-19, Druggability |
| Cite Article: | "In-silico screening of potential immune-boosting phytocompounds from several medicinal plants against SARS-CoV-2", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 6, page no.406 - 415, June-2022, Available :http://www.ijrti.org/papers/IJRTI2206070.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2206070
Registration ID:182394
Published In: Volume 7 Issue 6, June-2022
DOI (Digital Object Identifier):
Page No: 406 - 415 Country: Belagavi, Karnataka, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2206070 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2206070 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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