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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Formulation and Evaluation Of Microsphere With Telmisartan Drug By Ionotropic Gelation Method |
| Authors Name: | Himanshu C Chaudhari , Latesh Y Chaudhari , Pratik A Chaudhari , Shubham P Bhavsar , Sandip A Tadavi |
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IJRTI_182755
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| Published Paper Id: | IJRTI2206220 |
| Published In: | Volume 7 Issue 6, June-2022 |
| DOI: | |
| Abstract: | Microsphere is novel drug delivery system for improving therapeutic action of drug, increasing prolong action lowering dose frequency of dosage form and to improve patient complies. Microsphere are small micron size particle ranging from 1um to 1000 um and are free flowing particle prepared to acquired prolonged and controlled drug delivery to enhance the drug bioavailability and stability and target specific sites The main aim of the present study was to formulate Telmisartan microspheres by ionotropic gelation technique using various polymer such as Carbopol grade 940, sodium alginate, chitosan etc. where 8-10 % calcium chloride is used as a cross linking agent to form a discrete microsphere with sodium alginate for the effective use in the treatment of hypertension. Prepared microsphere was evaluated for entrapment efficiency, drug content. Microsphere size, morphology, FTIR, DSC, in vitro drug release and drug release kinetics. The prepared microsphere was bulky, free flowing, spherical and showed a drug entrapment ranging between 50 – 80 % and had a mean particle size ranging from as determined by optical microscopy and SEM (showed microsphere with spherical and rough surface) and the percent yield range between 80 to 98.94 %. The size of microsphere was increasing by increasing concentration of alginate and increasing concentration of polymer (Carbopol and chitosan). The in vitro drug release was carried out in Phosphate buffer (PH 7.8). Percent drug release was decreased and increased in concentration of sodium alginate and calcium chloride. The present study conclusively that telmisartan microsphere could be prepared successfully and formulation F4 shows satisfactory result. Telmisartan microspheres were developed to control the release rate of the drug and target to specific site of the body to make an enormous impact in the formulation and development of novel drug delivery system and also improve efficient absorption and enhances oral bioavailability of the drug due to high surface to volume ratio. |
| Keywords: | Microsphere, Bioavailability, sustained release, Targeted drug delivery, Hypertension, Sodium alginate, Carbopol. |
| Cite Article: | "Formulation and Evaluation Of Microsphere With Telmisartan Drug By Ionotropic Gelation Method", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 6, page no.1489 - 1500, June-2022, Available :http://www.ijrti.org/papers/IJRTI2206220.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2206220
Registration ID:182755
Published In: Volume 7 Issue 6, June-2022
DOI (Digital Object Identifier):
Page No: 1489 - 1500 Country: Shahada, MAHARASHTRA, India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2206220 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2206220 |
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ISSN: 2456-3315
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