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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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| Paper Title: | transdermal drug delivery system |
| Authors Name: | HANNA |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJRTI_182693
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| Published Paper Id: | IJRTI2206313 |
| Published In: | Volume 7 Issue 6, June-2022 |
| DOI: | |
| Abstract: | Transdermal delivery of medications was foreshadowed in earlier eras by the use of certain plasters and ointments. The mustard plaster, applied as a home remedy for severe chest congestion, may be considered an example.the most remarkable forerunner of modern transdermal medication was Stronger Mercurial Ointment, used as a treatment for syphilis when Salvarsan and other arsenicals were in use, before the discovery of penicillin Today, transdermal drug delivery (TDD) utilizes the skin as a portal to deliver drugs into the systemic circulation. The development of the first transdermal therapeutic system or “patch” containing scopolamine for motion sickness in the early 1980s heralded the start of this route becoming a viable treatment option.Transdermal drug delivery systems are defined as self-contained, self- discrete dosage forms which when applied to the intact skin deliver the drug at the controlled rate to the systemic circulation.A transdermal patch is defined as medicated adhesive patch which is placed above the skin to deliver a specific dose of medication through the skin with a predetermined rate of release to reach into the bloodstream. TDD is a painless method of delivering drugs systemically by applying a drug formulation onto intact and healthy skin.The drug initially penetrates through the stratum corneum and then passes through the deeper epidermis and dermis without drug accumulation in the dermal layer. When drug reaches the dermal layer, it becomes available for systemic absorption via the dermal microcirculation.Transdermal drug delivery systems provide an easy, reliable mechanism of administering drugs when rapid onset is not important. Transdermal drug delivery bypasses the enter hepatic circulation, thereby providing a more reliable clinical action. With many drugs, the efficacy of transdermal delivery is equivalent to that of a continuous IV infusion, yet in a non-invasive system.Transdermal drug delivery system use skin as site of administration and it has large number of advantages it reduces the need of frequent dosing as a single patch can be used to deliver the drug for 1 to 7 days so causes no worry to patient if he/she forget to take the medicine. Due to its greater patient compliance the demand of TDS is increasing with time.Now several transdermal products are being marketed successfully incorporating drugs, such as clonidine, nicotine, scopolamine, nitroglycerin, estradiol, and fentanyl. The market value for Recently, physical enhancement systems are being reported as having big potential by many researchers. In particular, iontophoresis is a very attractive way of delivering ionized drugs by the application of an electric field to the skin. This has been marketed with some topical and systemic drugs (lidocaine and fentanyl). Sonophoresis is also an attractive method to deliver a drug through the skin using ultrasound. Besides these technologies, various physical approaches are under study. Such technologies can be expected to deliver not only small MW compounds but also macromolecules like peptidesTDDS are dosage forms designed to deliver a therapeutically effective amount of drug across a patient's skin. The main objective of transdermal drug delivery system is to deliver drugs into systemic circulation into the skin through skin at predetermined rate with minimal inter and intra patient variation.Transdermal drug delivery systems are used in various skin disorders, also in the management of angina pectoris, pains, smoking cessation & neurological disorders such as Parkinson’s disease. |
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| Cite Article: | "transdermal drug delivery system", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 6, page no.2080 - 2086, June-2022, Available :http://www.ijrti.org/papers/IJRTI2206313.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2206313
Registration ID:182693
Published In: Volume 7 Issue 6, June-2022
DOI (Digital Object Identifier):
Page No: 2080 - 2086 Country: srinagar, kashmir, India Research Area: Health Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2206313 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2206313 |
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ISSN: 2456-3315
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