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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
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Issue Published : 118
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| Paper Title: | DEVELOPMENT AND VALIDATION FOR HPLC METHOD OF ESTIMATION OF MOXIFLOXACIN IN EYE DROP FORMULATION |
| Authors Name: | Komal V Shende , Anil P. Dewani , Yogesh B. Bawne , Nilesh O. Chachda |
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IJRTI_184793
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| Published Paper Id: | IJRTI2212033 |
| Published In: | Volume 7 Issue 12, December-2022 |
| DOI: | |
| Abstract: | Abstract: Moxifloxacin shows most effectiveness towards antibacterial antibiotic activity, as in eye drops. It is marketed worldwide under the brand name 4-Quin. We have developed a HPLC method to estimate Moxifloxacin from an eye drop formulation. For effectiveness Moxifloxacin 98% Purity was used. Sodium acetate buffer and Methanol were taken as a mobile phase. For identifying and determining Moxifloxacin, the Younglin HPLC system was used. The assay of Moxifloxacin 98.24% was at the standard limit of 90.0 % to 110.0 % by Trial and test Sample Observation. Y=22.563x+13.923 and R2= 0.9994 Linearity was observed in 4 trials of Standard Moxifloxacin. The SD of the peak area and the slop of the calibration curve of Moxifloxacin was found to be 23.37µg and its lineality was found to be y=-29.25x+124.8 and R 2 = 0.645. The repeatability on Interday and interraday precision was found to be above 99%.There was not any deviation under subjected to stress with 5N HCl, 5N NaOH, 3% H2O2; 105°C, UV and Thermal degradation at 600C in presence of 80% RH. Validate 100% Recovery with Moxifloxacin assay. The Project’s objectives were successful when compared with the marketed product. |
| Keywords: | Key words: Moxifloxacin, Eye Drop, Development, Validation, Formulation, Antibacterial |
| Cite Article: | "DEVELOPMENT AND VALIDATION FOR HPLC METHOD OF ESTIMATION OF MOXIFLOXACIN IN EYE DROP FORMULATION", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 12, page no.245 - 265, December-2022, Available :http://www.ijrti.org/papers/IJRTI2212033.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2212033
Registration ID:184793
Published In: Volume 7 Issue 12, December-2022
DOI (Digital Object Identifier):
Page No: 245 - 265 Country: Yawatmal, Maharastra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2212033 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2212033 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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