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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 118
Article Submitted : 21664
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Total Authors : 22459
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| Paper Title: | Investigating the Role of Ultrasonic Melt Sonocrystallization in the Development of Enhanced Oral Anticoagulant Therapies. |
| Authors Name: | S.D. Paralkar , Y.S. Thorat , B.D. Tiwari , S.L.Gavali , R.B.Gadhave |
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IJRTI_204484
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| Published Paper Id: | IJRTI2506065 |
| Published In: | Volume 10 Issue 6, June-2025 |
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| Abstract: | The present research focuses on the formulation and evaluation of Rivaroxaban crystals using the melt sonocrystallization technique to overcome its poor aqueous solubility and limited oral bioavailability. As a BCS Class II drug, Rivaroxaban exhibits low dissolution rates, which directly impacts its therapeutic performance. Melt sonocrystallization, an innovative crystal engineering method, utilizes controlled ultrasonic energy during the melt phase to induce rapid nucleation and uniform crystal growth, resulting in fine and stable crystalline particles. In this study, rivaroxaban was melted sonocrystallized at optimal circumstances to produce crystals with enhanced solubility and dissolving properties. The produced crystals were evaluated for particle size, shape, crystallinity, and thermal behaviour using a variety of physicochemical techniques. Particle size was significantly reduced, and the rates of dissolving were improved, in comparison to the pure medication. This enhancement is attributed to increased surface area, reduced crystallite size, and modified crystal habit induced by ultrasonic cavitation. Melt sonocrystallization presents a simple, solvent-free, and scalable approach for improving the performance of poorly soluble drugs. The study concludes that this method is a viable alternative for enhancing the bioavailability of Rivaroxaban and potentially other low-solubility therapeutic agents. |
| Keywords: | Melt sonocrystallization, Rivaroxaban, Solubility, Crystallization, Bath Sonicator. |
| Cite Article: | "Investigating the Role of Ultrasonic Melt Sonocrystallization in the Development of Enhanced Oral Anticoagulant Therapies. ", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 6, page no.a561-a570, June-2025, Available :http://www.ijrti.org/papers/IJRTI2506065.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2506065
Registration ID:204484
Published In: Volume 10 Issue 6, June-2025
DOI (Digital Object Identifier):
Page No: a561-a570 Country: Solapur, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2506065 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2506065 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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