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Published Paper Details
Paper Title:
A Behavioural Study of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Relation to Risk Factors: Drug-Drug Interactions, Age, Elevated Serum Creatinine, and Pain Score Variations
Authors Name:
Prapti Sonawane
, Gauri Thawali , Dr.Vaishali Pardeshi , Dr.Rahul Surve , Dr. Trupti Tuse
ABSTRACT
Objective: This paper aims to examine the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on patients and promote the safe use of these medications. It includes a behavioural study of NSAIDs, focusing on outcomes such as changes in pain scores, drug-drug interactions, and variations in serum creatinine levels. Special attention is given to age-related differences in serum creatinine and the identification of high-risk groups that are more susceptible to elevated creatinine levels. These findings can contribute to better prevention of NSAID-induced nephrotoxicity.
Method: This is a prospective observational study conducted at a tertiary care hospital, with a total sample size of 223 participants.
Result: A total of 223 patients were included in the study. Of these, 133 (59.64%) were male and 90 (40.35%) were female. The commonly prescribed drugs in the study included diclofenac, aceclofenac, paracetamol, etoricoxib, aspirin, and naproxen.
A total of 24 drug interactions were identified, most of which were classified as minor drug-drug interactions. Pain scores were recorded using a numerical rating scale: 94 patients had a pain score of 0, 91 had a score of 1, 36 had a score of 2, and 2 patients had a score of 3.
Regarding renal function, 42 elderly patients (aged over 50 years) had serum creatinine levels greater than 1 mg/dL. In comparison, 15 patients aged between 15 and 50 years also had serum creatinine levels above 1 mg/dL.
Conclusion: The study aims to understand variations in drug effects based on different factors and conditions included in the analysis. These insights will assist healthcare providers in enhancing individual risk assessment and tailoring treatment plans accordingly.
Keywords:
Keywords: Safe use of NSAIDs, Risk factors, Drug interactions, Pain score observation, Polypharmacy, Serum Creatinine.
Cite Article:
"A Behavioural Study of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Relation to Risk Factors: Drug-Drug Interactions, Age, Elevated Serum Creatinine, and Pain Score Variations", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 6, page no.b216-b224, June-2025, Available :http://www.ijrti.org/papers/IJRTI2506129.pdf
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ISSN:
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator