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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Dioscorea bulbifera-Loaded Phytosomes as a Novel Cardioprotective Agent: A Study on Antioxidant and Pro-Angiogenic Activity |
| Authors Name: | Anjali V. Mahalkar , Dr. Swati Patil |
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| Author Reg. ID: |
IJRTI_204970
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| Published Paper Id: | IJRTI2506175 |
| Published In: | Volume 10 Issue 6, June-2025 |
| DOI: | https://doi.org/10.56975/ijrti.v10i6.204970 |
| Abstract: | The COVID-19 pandemic highlighted the importance of cardiovascular health, emphasizing the need for cardioprotective strategies. Cardiovascular disease (CVD), primarily due to atherosclerosis, remains the leading global cause of mortality. A promising therapeutic approach is revascularization through pro-angiogenesis, which enhances blood vessel formation to restore circulation in ischemic tissues. Dioscorea bulbifera, a member of the family Dioscoreaceae, traditionally used for wound healing, contains diosgenin, a bioactive compound known to modulate vascular pathways. However, its pro-angiogenic potential remains unexplored. This study involves extraction and yield optimization of Dioscorea bulbifera tuber bio actives, followed by phytochemical screening and standardization using UV spectroscopy and Thin Layer Chromatography. Phytosomes were formulated using the solvent injection method and characterized by measuring particle size, zeta potential, and entrapment efficiency. Antioxidant activity was evaluated using the DPPH assay & the pro-angiogenic potential was evaluated through the Chick Chorioallantoic Membrane (CAM) assay, wherein it was found that Dioscorea phytosome formulation induced more pro-angiogenesis as compared to the crude extract. Thus, these findings confirm the antioxidant capacity and suggest a promising pro-angiogenic potential of D. bulbifera, that can hence be explored as a possible novel candidate for cardiovascular protection, within phytosomes can provide a strategic approach for enhanced cardio protection. |
| Keywords: | Dioscorea bulbifera, cardiovascular protection, phytosomes, pro-angiogenesis, and antioxidant |
| Cite Article: | "Dioscorea bulbifera-Loaded Phytosomes as a Novel Cardioprotective Agent: A Study on Antioxidant and Pro-Angiogenic Activity", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 6, page no.b630-b637, June-2025, Available :http://www.ijrti.org/papers/IJRTI2506175.pdf |
| Downloads: | 000482 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID: IJRTI2506175
Registration ID:204970
Published In: Volume 10 Issue 6, June-2025
DOI (Digital Object Identifier): https://doi.org/10.56975/ijrti.v10i6.204970
Page No: b630-b637 Country: Mumbai, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2506175 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2506175 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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